A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/13 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01)
Patent
CA 2190485
A pharmaceutical composition is disclosed in the form of a nonirrtating emulsion which includes at least one cyclosporin in admixture with a higher fatty acid glyceride and polysorbate 80. More particularly, the cyclosporin may be cyclosporing A and the higher fatty acid glyceride may be castor oil. Composition has been found to be of a high comfort level and low irritation potential suitable for delivery of medications to sensitive areas such as ocular tissues with enhanced absorption in the lacrimal gland. In addition, the composition has stability for up to nine months without crystallization of cyclosporin.
Préparation pharmaceutique sous forme d'émulsion non irritante comprenant au moins une cyclosporine mélangée à un glycéride d'acide gras supérieur et à du polysorbate 80. La cyclosporine peut plus particulièrement être du type A, et l'acide gras, de l'huile de ricin. Ladite préparation qui présente un niveau élevé de confort et un faible potentiel irritatif, convient pour l'administration de médications destinés à des zones sensibles telles que les tissus de l'oeil, et présente une forte absorption au niveau des glandes lacrymales. Elle reste stable jusqu'à neuf mois sans que la cyclosporine ne cristallise.
Ding Shulin
Olejnik Orest
Tien Walter L.
Allergan
Allergan Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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