Lactam dipeptides having hle inhibiting activity

Details Lactam dipeptides having hle inhibiting activity Lactam dipeptides having hle inhibiting activity

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) C07D 213/76 (2006.01) C07D 401/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07F 9/59 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2132543

2132543 9321212 PCTABS00027 The present invention relates to certain novel heterocyclic compounds which are 1-pyridylacetamide compounds of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic compounds, processes for preparing the heterocyclic compounds, pharmaceutical compositions containing such heterocyclic compounds and methods for their use.

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