Lactam inhibitors of hepatitis c virus ns3 protease

Details Lactam inhibitors of hepatitis c virus ns3 protease Lactam inhibitors of hepatitis c virus ns3 protease

C - Chemistry, Metallurgy

07

D

C07D 207/26 (2006.01) A61K 31/4015 (2006.01) A61K 31/45 (2006.01) A61K 31/55 (2006.01) A61K 33/22 (2006.01) A61P 31/14 (2006.01) C07D 211/76 (2006.01) C07D 223/10 (2006.01) C07D 233/12 (2006.01) C07F 5/02 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2376961

The present invention relates to lactams of Formula (I) or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HCV NS3 protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

L'invention concerne des lactames de la formule (I), des formes stéréoisomères, des mélanges stéréoisomères ou leurs formes de sels pharmaceutiquement acceptables, qui sont utiles en tant qu'inhibiteurs de la protéase NS3 du VHC, ainsi que des compositions pharmaceutiques et des trousses de diagnostic les renfermant. Elle concerne enfin leurs procédés d'utilisation pour traiter des infections virales ou comme solution étalon ou réactif pour le dosage.

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