Lactam metalloprotease inhibitors

Details Lactam metalloprotease inhibitors Lactam metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4015 (2006.01) A61P 29/00 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 207/273 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2415505

The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide comprising 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.

L'invention concerne des lactames et des dérivés de lactame représentés par la formule (I), ou leurs sels pharmaceutiquement acceptables. Dans ladite formule, le noyau B est une amide cyclique comportant entre 4 et 8 éléments, qui renferme de 0 à 3 hétéroatomes additionnels choisis parmi N, O et S. Les produits considérés sont utiles comme inhibiteurs de métalloprotéase.

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