Lactam-n-acetic acids and their amides

Details Lactam-n-acetic acids and their amides Lactam-n-acetic acids and their amides

C - Chemistry, Metallurgy

07

D

260/278, 260/292

C07D 207/27 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 207/26 (2006.01) C07D 211/76 (2006.01) C07D 223/10 (2006.01) C07D 227/08 (2006.01)

Patent

CA 1119593

ABSTRACT OF THE DISCLOSURE: New lactam-N-acetic acids and amides thereof having the formula Image wherein R1 and R2 = H, C1-C4 alkyl, aryl or halogen- substituted aryl, R3 = OH or -NR4R5, R4 and R5 = H, C1-C4alkyl, cycloalkyl, aralkyl or, taken together with the N atom form alkyleneimino, oxa-alkyleneimino, aza-alkyleneimino or N-benzyl-aza- alkyleneimino, m is 3, 4 or 5, preferably 3, n is 0, 1 or 2, preferably 2; and the pharmaceutically acceptable salts of said acids. Processes for producing these compounds and pharmaceutical compositions containing the same are also given. These compounds show amongst others beneficial activity on the mnemic processes and cardiac activity.

325925

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