Lactam polymer derivatives

C - Chemistry – Metallurgy – 08 – F

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C08F 8/04 (2006.01) C08F 8/00 (2006.01) C08F 26/06 (2006.01) C08G 18/83 (2006.01) C08L 101/14 (2006.01) C09B 69/10 (2006.01) G02B 1/04 (2006.01)

Patent

CA 2582896

Lactam polymers have been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups ' are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting lactam polymer derivatives are useful as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.

Selon l'invention, des polymères de lactam ont été modifiés avec du borohydrure de sodium (NaBH4) de manière à produire des polymères de lactam portant des groupes fonctionnels hydroxyle. Ces groupes fonctionnels sont utilisés en vue d'une liaison covalente de groupes réactifs, de sondes fluorescentes, d'agents antimicrobiens, de facteurs bioactifs, et de médicaments. Ces derniers sont utilisés en tant que composants de dispositifs médicaux, notamment, de dispositifs ophtalmiques et, plus spécifiquement encore, de lentilles de contact. Des hydrogels à base de ces polymères sont également employés dans des applications biomédicales, dans les domaines d'administration de médicaments, d'ingénierie tissulaire et de dispositifs implantables.

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