A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61P 25/28 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01)
Patent
CA 2401120
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.
L'invention concerne de nouveaux lactames représentés par la formule générale (I), leurs compositions pharmaceutiques et leurs procédés d'utilisation. Ces nouveaux composés inhibent le traitement de la protéine précurseur amyloïde et, d'une manière plus spécifique, inhibent la production de peptides A.beta., prévenant ainsi la formation de dépôts neurologiques de la protéine amyloïde. Plus particulièrement, l'invention concerne le traitement de troubles neurologiques liés à la production de la protéine .beta.-amyloïde, notamment la maladie d'Alzheimer et le syndrome de Down.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
LandOfFree
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