C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/18 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61P 25/28 (2006.01) C07D 223/12 (2006.01) C07D 223/16 (2006.01) C07D 243/12 (2006.01) C07D 243/14 (2006.01) C07D 243/24 (2006.01)
Patent
CA 2379445
This invention relates to novel lactams having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.
Cette invention a trait à de nouveaux lactames correspondant à la formule (I), à leurs compositions pharmaceutiques et à leurs techniques d'utilisation. Ces nouveaux composés, qui inhibent le traitement d'une protéine précurseur amyloïde et, plus précisément, inhibent la production d'un peptideA beta , ont une action préventive contre la formation de dépôts neurologiques de protéine amyloïde. Cette invention concerne, notamment, le traitement de troubles neurologiques liés à la production d'amyloïde beta , tels que la maladie d'Alzheimer et le syndrome de Down.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
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