Lactic acid bacteria having action of lowering blood uric...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/20 (2006.01)

Patent

CA 2718157

Various lactic acid bacteria were cultured in the presence of a purine body and the consumed amount of the purine body, the produced amount of degradation products of the purine body were measured, and a plurality of lactic acid bacteria which had a remarkable degradation ability of purine body were selected. Any of the lactic acid bacteria which were judged to have a high degradation ability of purine body by the selection was orally administered to rats raised with a purine body-containing feed, the general status of the rats and the blood uric acid level in the rats were determined, and the effect of administration of lactic acid bacteria on the serum uric acid level was studied. As a result, lactic acid bacteria: Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779 which significantly reduce an increase of the serum uric acid level were found.

Diverses bactéries lactiques ont été cultivées en présence d'un corps purique et la quantité consommée du corps purique et la quantité produite de produits de dégradation du corps purique ont été mesurées, et une pluralité de bactéries lactiques montrant une capacité de dégradation remarquable de corps purique a été sélectionnée. Toutes les bactéries lactiques dont la sélection a permis d'estimer qu'elles avaient une capacité élevée de dégradation de corps purique ont été administrées par voie orale à des rats élevés avec une alimentation contenant un corps purique, l'état général des rats et la teneur en acide urique dans le sang des rats ont été déterminés, et l'effet de l'administration des bactéries lactiques sur la teneur sérique en acide urique a été étudié. En résultat, les bactéries lactiques Lactobacillus gasseri OLL2959 et Lactobacillus oris OLL2779 réduisant significativement une augmentation de la teneur sérique en acide urique ont été découvertes.

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