Lactic acid polymer and process for producing the same

Details Lactic acid polymer and process for producing the same Lactic acid polymer and process for producing the same

C - Chemistry, Metallurgy

08

G

C08G 63/88 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 47/34 (2006.01) C08G 63/08 (2006.01) C08G 63/91 (2006.01)

Patent

CA 2419065

A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.

Procédé servant à préparer un polymère d'acide lactique possédant un poids moléculaire moyen de 15 000 à 50 000 et un contenu de constituants polymères dont le poids moléculaire moyen égal ou inférieur à 5 000 correspond à un pourcentage en poids égal ou inférieur à 5. Ce procédé consiste à hydrolyser un polymère d'acide lactique possédant une teneur moléculaire élevée, à mettre la solution obtenue contenant les hydrolysats dans des conditions permettant au polymère d'acide lactique ciblé contenu dans ladite solution de former un précipité et à isoler ce précipité. Ce polymère d'acide lactique est utile en tant que base de médicament à libération prolongée, ce qui empêche les microgélules contenant une substance active sur le plan physiologique de libérer une quantité excessive de ladite substance dans un stade initial et permet de maintenir la stabilité du débit de libération sur une durée prolongée.

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