Lactoferrin receptor genes of moraxella

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) C07K 14/195 (2006.01) A61K 39/00 (2006.01) C07K 14/79 (2006.01)

Patent

CA 2292838

Purified and isolated nucleic acid molecules are provided which encode lactoferrin receptor proteins of Moraxella, such as M. catarrhalis, or a fragment or an analog of the lactoferrin receptor protein. The nucleic acid sequence may be used to produce recombinant lactoferrin receptor proteins Lbp1, Lbp2 or ORF3 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.

L'invention concerne des molécules d'acide nucléique isolées et purifiées qui codent pour les protéines du récepteur de la lactoferrine de Moraxella, notamment de M. catarrhalis, ou pour un fragment ou un analogue desdites protéines. Cette séquence d'acide nucléique peut être utilisée pour produire les protéines du récepteur de la lactoferrine recombinantes Lbp1, Lbp2 et ORF3 de la souche de Moraxella, sans autres protéines de ladite souche, à des fins diagnostiques et thérapeutiques. La molécule d'acide nucléique peut également être utilisée pour le diagnostic de l'infection.

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