C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/79 (2006.01)
Patent
CA 2256453
The present invention is directed to recombinant nucleic acids encoding lactoferrin variants and portions thereof, having modified iron-binding capacity, and to vectors comprising same recombinanat nucleic acids. The present invention is further directed to methods of producing such vectors, and to transfected cells harboring the same. Methods for the production of lactoferrin variants and portions thereof, in various eukaryotic or prokaryotic cells are also provided. Finally, the invention is directed to lactoferrin variants and portions thereof encoded by the nucleic acids of the invention and produced by the processes of the invention. Thus, the invention provides an efficient and economical means for the production of recombinant lactoferrin variants and portions thereof.
La présente invention concerne des acides nucléiques recombinants qui encodent des variantes de lactoferrine et des fractions desdites variantes ayant des capacités modifiées de fixation du fer et des vecteurs comprenant lesdits acides nucléiques recombinants. La présente invention concerne également des procédés de production desdits vecteurs et des cellules transfectées abritant lesdits vecteurs. L'invention concerne en outre des procédés de production de variantes de lactoferrine et de fractions desdites variantes dans de nombreuses cellules eucaryotes ou procaryotes. L'invention concerne enfin des variantes de lactoferrine et des fractions desdites variantes encodées par les acides nucléiques de l'invention et produites selon les procédés de l'invention. L'invention décrit ainsi un moyen efficace et économique de produire des variantes de lactoferrine et des fractions desdites variantes.
Conneely Orla M.
Ward Pauline P.
Baylor College Of Medicine
Smart & Biggar
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