Lactol derivatives, their production and use

Details Lactol derivatives, their production and use Lactol derivatives, their production and use

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) C07D 307/22 (2006.01) C07D 309/14 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01) C07F 9/547 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2131397

Abstract of the Disclosure The present invention provides novel compound of the formulas (Ia) or (I): Image (Ia) wherein Q is one or two amino acid residues which may be substituted; R3 is a carboxyl group which may be esterified or an acyl group; A is an alkylene group; B is hydrogen or an alkyl group which may be substituted or an acyl group; or a salt thereof; Image (I) wherein R1 and R2 may be the same or different and each is hydrogen or a hydrocarbon residue which may be substituted; R3, A and B have the same definitions as those shown above; m and n each is o or 1; provided that where both m and n are both equal to 0, R3 is a carboxyl group which may be esterified or an acyl group having not less than 7 carbon atoms; or a salt thereof. The compound (Ia) or (I) shows cathepsin L inhibitory and bone resorption inhibitory activities and are useful as a prophylactic/therapeutic agent for osteoporosis.

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