Lactone bearing absorbable polymers

Details Lactone bearing absorbable polymers Lactone bearing absorbable polymers

C - Chemistry, Metallurgy

08

G

C08G 63/08 (2006.01) A61K 9/14 (2006.01) A61K 38/08 (2006.01) A61K 38/09 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) C08G 64/00 (2006.01) C08G 67/04 (2006.01) C08G 79/02 (2006.01)

Patent

CA 2349346

The present invention pertains to biodegradable polymers comprising a non- polymerizable lactone, biodegradable compositions comprising the polymer and a therapeutic agent, the use of the compositions for the sustained release of therapeutic agents, wherein the therapeutic agent is reversibly immobilized on the polymer matrix using ionic complexation between the latent carboxylic groups present on the lactone bearing polymer matrix and a cationic group on the therapeutic agent.

La présente invention concerne des polymères biodégradables comprenant une lactone non polymérisable, des compositions biodégradables contenant lesdits polymères et un agent thérapeutique, ainsi que l'utilisation de ces compositions pour la libération prolongée d'agents thérapeutiques. Dans ces polymères, l'agent thérapeutique est immobilisé de façon réversible sur la matrice polymère par formation d'un complexe ionique entre les groupes carboxyliques latents présent sur ladite matrice portant la lactone et un groupe cationique situé sur l'agent thérapeutique.

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