Lactonization process

Details Lactonization process Lactonization process

C - Chemistry, Metallurgy

07

D

C07D 309/30 (2006.01)

Patent

CA 2388182

Crystalline 3-hydroxylactone-containing products can be prepared in high yield and purity in a one-pot process by treating the corresponding 3,5-dihydroxy acid with a strong mineral acid in a cold, aprotic, water-miscible solvent to effect lactonization, followed by addition of excess acid to effect crystallization of the lactonized product from the reaction mixture.

La présente invention concerne un processus monotope grâce auquel on peut préparer avec un rendement élevé des produits cristallins contenant une hydroxylactone-3 d'une grande pureté en traitant l'acide dihydroxy-3,5 correspondant avec un acide minéral fort dans un solvant froid, aprotique, miscible avec l'eau afin d'entraîner une lactonisation, après laquelle on ajoute l'acide excédentaire afin de provoquer la cristallisation du produit lactonisé obtenu à partir du mélange réactionnel.

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