Lactose-free, non-hygroscopic and anhydrous pharmaceutical...

Details Lactose-free, non-hygroscopic and anhydrous pharmaceutical... Lactose-free, non-hygroscopic and anhydrous pharmaceutical...

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 9/20 (2006.01) A61K 31/4545 (2006.01) A61K 31/60 (2006.01)

Patent

CA 2267136

Stable pharmaceutical compositions of descarboethoxyloratadine (DCL), a metabolic derivative of loratadine, for the treatment of allergic rhinitis and other histamine-induced disorders are disclosed. The compositions are formulated to avoid the incompatibility between DCL and reactive excipients such as lactose and other mono- and di- saccharides. Disclosed compositions include lactose-free, non-hygroscopic and anhydrous stable pharmaceutical compositions of DCL.

La présente invention a trait à des compositions pharmaceutiques stables de descarboéthoxyloratadine (DLC) qui est un dérivé métabolique de la loratadine, destinées au traitement de la rhinite allergique et d'autres troubles engendrés par l'histamine. Les compositions sont formulées de manière à éviter l'incompatibilité entre le DCL et les excipients réactifs tels que le lactose, et d'autres monosaccharides et disaccharides. Les compositions de cette invention renferment des compositions pharmaceutiques de DCL exemptes de lactose, non hygroscopiques, anhydres et stables.

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