Lag-3 protein soluble polypeptide fractions, method of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189657

Soluble polypeptide fraction consisting of all or part of one at least of the four immunoglobulin-type extracellular LAG-3 protein domains (aminoacid 1-159, 160-239, 240-330 and 331-412 of the SEQ ID N~ 1 sequence) or consisting of one peptide sequence derived from these domains by replacement, addition or deletion of one or more aminoacids. The fraction of the invention has a specificity at least equal to that of LAG-3 in relation to its ligand.

L'invention concerne une fraction polypeptidique soluble constituée par tout ou partie de l'un au moins des 4 domaines extracellulaires de type immunoglobuline de la protéine LAG-3 (aminoacide 1 à 159, 160 à 239, 240 à 330 et 331 à 412 de la séquence SEQ ID N° 1) ou par une séquence peptidique dérivant de ces domaines par remplacement, addition et ou délétion d'un ou plusieurs aminoacides, et qui possède une spécificité au moins égale à celle de LAG-3 pour son ligand.

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