Lag-3 splice variants

Details Lag-3 splice variants Lag-3 splice variants

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2293735

This invention concerns an isolated nucleotidic sequence selected from the group consisting of: a) the nucleotidic sequences SEQ ID NO 1, SEQ ID NO 3 or SEQ ID NO 5; b) the nucleotidic sequences which hybridize under stringent conditions to any of the sequences defined in a) and which code for a polypeptide which is a variant of the LAG-3 molecule; c) the nucleotidic sequences which are degenerated as results of the genetic code to the nucleotidic sequences defined in a) and b), and which code for a polypeptide which is a genetic variant of the LAG-3 molecule.

L'invention concerne une séquence nucléotidique isolée, choisie dans le groupe comprenant: a) les séquences nucléotidiques SEQ ID NO 1, SEQ ID NO 3 ou SEQ ID NO 5, b) les séquences nucléotidiques qui s'hybrident dans des conditions strictes à l'une quelconque des séquences nommées en a) et qui codent pour un polypeptide qui est un variant de la molécule LAG-3, et c) les séquences nucléotidiques qui sont soumises à une dégénérescence liée au code génétique, afin d'obtenir les séquences nucléotidiques définies en a) et b), et qui codent pour un polypeptide qui est un variant génétique de la molécule LAG-3.

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