Laglidadg homing endonuclease variants having novel...

Details Laglidadg homing endonuclease variants having novel... Laglidadg homing endonuclease variants having novel...

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01)

Patent

CA 2678526

A LAGLIDADG homing endonuclease variant having novel substrate specificity, said variant being obtainable by a method comprising : (a) the mutation of at least one amino acid residue of the final C-terminal loop of a parent LAGLIDADG homing endonuclease, with the exclusion of the threonine 140 of I-CreI, b) the selection and/or screening of the variants from step (a) having a pattern of cleaved DNA targets that is different from that of the parent LAGLIDADG homing endonuclease.

L'invention porte sur un variant d'endonucléase homing LAGLIDADG à une nouvelle spécificité de substrat. Ce variant peut être obtenu par un procédé comprenant : (a) la mutation d'au moins un résidu d'acide aminé de la boucle C-terminale finale d'une endonucléase homing LAGLIDADG parente, à l'exclusion de la thréonine 140 de I-CreI, b) la sélection et/ou le criblage des variants provenant de l'étape (a) à un motif de cibles d'ADN clivées différent de celui de l'endonucléase homing LAGLIDADG parente.

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