Laminins, derivatives, and compositions including same and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/195 (2006.01) A61K 38/39 (2006.01) A61P 43/00 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2739719

In various embodiments, the present disclosure provides a method of treating a subject using laminin or a composition that includes laminin. In one embodiment, the method is used to enhance muscle regeneration, maintenance, or repair in a subject. In another embodiment, the method is used to promote wound healing. The method, in yet another embodiment, is used to prevent or reduce muscle damage or injury. In specific implementations of these methods, the laminin or composition that includes laminin is administered in a therapeutically effective amount. In some implementations, the laminin is a complete laminin protein. In other implementations, the laminin is a laminin fragment, a laminin derivative, or a laminin analogue.

Dans divers modes de réalisation, la présente invention concerne un procédé pour traiter un sujet avec de la laminine ou une composition contenant de la laminine. Dans un mode de réalisation, le procédé sert à améliorer la régénération, l'entretien ou la restructuration musculaire chez un sujet. Dans un autre mode de réalisation, le procédé sert à favoriser la cicatrisation. Dans un autre mode de réalisation encore, le procédé sert à prévenir ou à réduire les accidents ou les lésions musculaires. Dans des mises en uvre spécifiques de ces procédés, la laminine ou la composition la contenant sont administrées en une quantité thérapeutiquement efficace. Dans certaines mises en uvre, la laminine est une protéine de laminine entière. Dans d'autres mises en uvre, la laminine est un fragment de laminine, un dérivé de laminine, ou un analogue de laminine.

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