Lankacidin derivatives and production thereof

Details Lankacidin derivatives and production thereof Lankacidin derivatives and production thereof

C - Chemistry, Metallurgy

07

D

167/208, 260/242

C07D 493/08 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01)

Patent

CA 1307269

ABSTRACT OF THE DISCLOSURE The present invention provides lankacidin derivative of the formula [1] Image [1] In the formula, one of R1 and R2 is H and the other is -C(=X)R5 [where X is O or S and R5 are an organic residue] or R1 and R2 together form Image [where R6 is acyl, sulfonyl or alkoxycarbonyl and R7 is alkyl]; R3 and R4 are OH, halogen, azido or an organic residue. The lankacidin derivative [1] shows excellent antimicrobial activities and thus can be used for prophylaxis and treatment of infectious disease in animals.

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