G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/569 (2006.01) C07K 16/12 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2581102
The present invention provides a clostridial toxin substrate that contains (a) a lanthanide donor complex; (b) an acceptor having an absorbance spectrum overlapping the emission spectrum of the lanthanide donor complex; and (c) a clostridial toxin recognition sequence containing a cleavage site that intervenes between the lanthanide donor complex and the acceptor, where, under the appropriate conditions, resonance energy transfer is exhibited between the lanthanide donor complex and the acceptor.
La présente invention concerne un substrat de toxine clostridiale qui contient (a) un complexe donneur de lanthanides; (b) un accepteur ayant un spectre d'absorbance chevauchant le spectre d'émission du complexe donneur de lanthanides et (c) une séquence de reconnaissance de toxine clostridiale contenant un site de restriction qui intervient entre le complexe donneur de lanthanides et l'accepteur. Dans des conditions appropriées, le transfert d'énergie de résonance se voit entre le complexe donneur de lanthanides et l'accepteur.
Aoki Kei Roger
Gilmore Marcella A.
Steward Lance E.
Verhagen Marc
Williams Dudley J.
Allergan Inc.
Aoki Kei Roger
Gilmore Marcella A.
Gowling Lafleur Henderson Llp
Steward Lance E.
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