Lanthionine-containing antimicrobial compound

Details Lanthionine-containing antimicrobial compound Lanthionine-containing antimicrobial compound

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 38/16 (2006.01) C07K 14/31 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2186621

A lanthionine-containing antimicrobial peptide obtainable from Staphylococcus hyicus strain 664 and pharmaceutically acceptable acid addition salts thereof as well as pharmaceutical compositions comprising said peptide or its acid addition salts and DNA molecules encoding said peptide are described. The peptide is purified from the culture medium of Staphylococcus hyicus strain 664 and can be used in a method of treating or preventing mastitis in a mammal comprising administering to said mammal a pharmaceutically effective amount of the peptide or a pharmaceutically acceptable acid addition salt thereof to effectively treat mastitis or effectively to suppress the rate, severity, and duration of subsequent bacterial infection.

On décrit un peptide antimicrobien contenant de la lanthionine, susceptible d'être obtenu à partir de la souche 664 de Staphylococcus hyicus, les sels d'addition d'acide de ce peptide, acceptables sur le plan pharmacologique, de même que des compositions pharmaceutiques comprenant ce peptide ou les sels d'addition d'acide de celui-ci ainsi que des molécules d'ADN codant ledit peptide. On purifie ce peptide à partir d'un milieu de culture de souche 664 de Staphylococcus hyicus, et on peut l'utiliser dans un procédé de traitement ou de prévention de la mastite chez un mammifère, qui consiste à administrer audit mammifère une quantité, efficace sur le plan pharmacologique, du composé ou d'un des sels d'addition d'acide de celui-ci, afin de traiter efficacement la mastite ou de supprimer de façon sûre le taux, la sévérité et la durée de l'infection bactérienne consécutive à celle-ci.

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