C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 279/12 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2636042
The present invention provides compositions comprising lanthionine ketimine derivatives and thiomorpholine dicarboxylic acid derivatives, as well as processes for the preparation of such compounds. The invention also concerns the use of lanthionine, lanthionine ketimine (LK), LK derivatives, thiomorpholine dicarboxylic acid (TMDCA), and TMDCA derivatives. It concerns the use of these compounds for the treatment and/or prevention diseases, including diseases affecting the central nervous system. The invention provides for compounds and methods having antioxidant, anti-neuroinflammatory and neuroprotective activities. It also provides for compounds having the ability to pass through and/or be transported through cellular membranes, such the blood-brain barrier.
La présente invention concerne des compositions comprenant des dérivés de lanthionine-cétimine et des dérivés d'acide thiomorpholine-dicarboxylique, ainsi que des procédés pour la préparation de tels composés. L'invention concerne également l'utilisation de lanthionine, de lanthionine-cétimine (LK), de dérivés de LK, d'acide thiomorpholine-dicarboxylique (TMDCA) et de dérivés de TMDCA. L'invention concerne l'utilisation de ces composés pour le traitement et/ou la prévention de maladies, dont des maladies affectant le système nerveux central. L'invention concerne des composés et des procédés ayant des effets antioxydants, anti-neuro-inflammatoires et neuroprotecteurs. L'invention concerne également des composés susceptibles de passer à travers ou d'être transportés à travers les membranes cellulaires, telles que la barrière hémato-encéphalique.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oklahoma Medical Research Foundation
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