Lantibiotic biosynthetic gene clusters from a. garbadinensis...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/08 (2006.01) C07K 14/365 (2006.01)

Patent

CA 2637315

This invention relates to characterisation of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced according to this invention, utilizing genes from the characterised biosynthetic gene clusters.

L~invention concerne la caractérisation du groupe de gènes biosynthétiques de l~actagardine lantibiotique, l~identification d~une nouvelle variante de l~actagardine et son groupe biosynthétique et des procédés de production et d~utilisation de l~actagardine, d~une nouvelle variante de l~actagardine appelée actagardine B et de variantes des deux produites selon l~invention à partir de gènes des groupes de gènes biosynthétiques caractérisés.

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