C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/315 (2006.01) A01N 63/02 (2006.01) A61K 38/16 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2209893
Mutacin are bactericidal substances of proteinaceous natures produced by Streptococcus mutans. Lantibiotics are antibacterial substances containing posttranslationnally modified amino acids such as lanthionine. The present invention teaches a simple method of purifying mutacin B-Ny266 from Streptococcus mutans strain Ny266 to homogeneity. The present invention further teaches the primary amino acid sequence of mutacin B-Ny266 as well as its proposed modified structure. Further, the present invention teaches compositions comprising mutacin B-Ny266 as well as methods for the treatment and/or prophylaxy of bacterial infections comprising an administration of a suitable dose of composition comprising mutacin B-Ny266.
Les mutacines sont des substances bactéricides de nature protéinique, produites par Streptococcus mutans. Les lantibiotiques sont des substances bactéricides contenant des acides aminés modifiés par post-translation, comme la lanthionine. La présente invention donne une méthode simple pour purifier la mutacine B-Ny266 provenant de la souche Ny266 de Streptococcus mutans jusqu'à ce qu'elle soit homogène. La présente invention donne également la séquence primaire d'acides aminés de la mutacine B-Ny266 ainsi que sa structure modifiée proposée. Enfin, la présente invention divulgue des compositions renfermant la mutacine B-Ny266 ainsi que des méthodes pour le traitement et (ou) la prévention d'infections bactériennes, comme l'administration d'une dose appropriée d'une composition renfermant la mutacine B-Ny266.
Lacroix Christophe
Lapointe Gisele
Lavoie Marc
Mota-Meira Marilaine
Goudreau Gage Dubuc
Universite Laval
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