Lantibiotics and uses thereof

Details Lantibiotics and uses thereof Lantibiotics and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/19 (2006.01) A01N 53/02 (2006.01) A01N 63/00 (2006.01)

Patent

CA 2693307

The present invention provides isolated lantibiotics that inhibit Gram negative and Gram positive microbes. The lantibiotic includes an amino acid sequence, wherein the amino acid sequence of the compound and the amino acid sequence of SEQ ID NO:21 or SEQ ID NO:22 have at least 80% identity. The lantibiotics have the characteristic of inhibiting growth of a Gram negative microbe in conditions that do not damage the outer membrane of the Gram negative microbe. The present inven-tion also provides methods for making and using the lantibiotics.

La présente invention concerne des lantibiotiques isolés qui inhibent les microbes Gram négatif et Gram positif. Le lantibiotique comprend une séquence d'acides aminés, la séquence d'acides aminés du composé et la séquence d'acides aminés de SEQ ID N° : 21 ou SEQ ID N°: 22 présentant une identité d'au moins 80 %. Les lantibiotiques ont les caractéristiques d'inhiber la croissance d'un microbe Gram négatif dans des conditions qui n'endommagent pas la membrane extérieure du microbe Gram négatif. La présente invention concerne également des procédés de fabrication et d'utilisation de lantibiotiques.

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