Large area submucosal graft constructs and method for making...

A - Human Necessities – 61 – K

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A61K 35/38 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01) A61L 27/36 (2006.01)

Patent

CA 2211727

Multi-laminar tissue graft constructs, pseudoisotropic graft constructs and a method of preparing such constructs are described. Multi-laminar tissue graft constructs are prepared by fusing partially overlapped strips of submucosa tissue into a unitary graft construct by compressing the tissue under dehydrating conditions. Pseudoisotropic tissue graft constructs are prepared by overlapping a first strip of submucosa tissue with at least two strips of submucosa tissue orientated so that the longitudinal axis of each strip forms an angle of about 180~/N with the longitudinal axes of at least two other strips of submucosal tissue.

Constructions de greffons en tissu stratifié, de greffons pseudo-isotropes et leur procédé de préparation. On prépare les greffons de tissu stratifié en assemblant des bandes de tissu sous-muqueux se recouvrant partiellement de façon à former un greffon unitaire, en comprimant le tissu dans des conditions de déshydratation. On prépare les greffons de tissu pseudo-isotrope en recouvrant une première bande de tissu sous-muqueux d'au moins deux bandes de tissu sous-muqueux orientées de telle façon que l'axe longitudinal de chaque bande forme un angle d'environ 180·/N avec les axes longitudinaux d'au moins deux autres bandes de tissu sous-muqueux.

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