Large conductance calcium-activated k channel opener

Details Large conductance calcium-activated k channel opener Large conductance calcium-activated k channel opener

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/4025 (2006.01) A61P 13/00 (2006.01) C07D 207/337 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 333/28 (2006.01) C07D 405/04 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2501979

There are disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): wherein ring A is a 5-membered heterocyclic ring containing any one of O, N or S, which ring may be substituted by R4, R1 is aryl, heterocyclic or heterocycle-substituted carbonyl; R2 is hydrogen, halogen, carboxy, amino, alkyl, alkoxycarbonyl, alkenyl or cycloalkyl; R3 is aryl, heterocyclic or alkyl; and R4 is hydrogen or alkyl, each of substituents may be substituted, or a pharmaceutically acceptable salt thereof as an active ingredient.

L'invention concerne un élément d'ouverture de canal K activé par du calcium, à conductance élevée, comprenant un composé de formule (I). Dans cette formule, l'anneau A désigne un anneau hétérocyclique à 5 éléments contenant un élément quelconque parmi O, N ou S, cet anneau pouvant être substitué par R?4¿. R?1¿ désigne aryle, carbonyle hétérocyclique ou hétérocycle substitué; R?2¿ désigne hydrogène, halogène, carboxy, amine, alkyle, alkoxycarbonyle, alcényle ou cycloalkyle; R?3¿ désigne aryle, hétérocyclique ou alkyle; et R?4¿ désigne hydrogène ou alkyle, chaque substituant pouvant être substitué. L'invention concerne également un sel pharmaceutiquement acceptable de ceux-ci, en tant que principe actif.

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