Large, latent complexes of tgf-beta2 and tgf-beta3

C - Chemistry – Metallurgy – 07 – K

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C07K 14/71 (2006.01) C07K 14/495 (2006.01)

Patent

CA 2128784

The invention relates to large latent complexes of TGF-.beta.2 and TGF- .beta.3, and methods for isolating these. The complex con- sists of a dimerized form of TGF-.beta.2 or TGF-.beta.3, the appropriate latency associated peptide, and the latent TGF-.beta.1 binding pro- tein, referred to as LTBP. Also described is a protein which binds to all of TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3, but is immunologically distinct from LTBP, referred to as LTBP-2.

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