C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/71 (2006.01) C07K 14/495 (2006.01)
Patent
CA 2128784
The invention relates to large latent complexes of TGF-.beta.2 and TGF- .beta.3, and methods for isolating these. The complex con- sists of a dimerized form of TGF-.beta.2 or TGF-.beta.3, the appropriate latency associated peptide, and the latent TGF-.beta.1 binding pro- tein, referred to as LTBP. Also described is a protein which binds to all of TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3, but is immunologically distinct from LTBP, referred to as LTBP-2.
Heldin Carl-Henrik
Miyazono Kohei
Olofsson Anders
Borden Ladner Gervais Llp
Ludwig Institute For Cancer Research
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