Large, porous particles produced controlling humidity during...

Details Large, porous particles produced controlling humidity during... Large, porous particles produced controlling humidity during...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/72 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2439818

Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, for instance, as dew point, which is known to produce particles having a specified tap density or aerodynamic diameter. Particles having a volume median geometric diameter greater than about 5 microns and a tap density less than about 0.4 g/cm3 are preferred.

L'invention concerne la production de particules séchées par atomisation, possédant des caractéristiques aérodynamiques spécifiques, consistant à pulvériser finement une arrivée de liquide et à mettre en contact cette arrivée de liquide avec un gaz, par exemple, de l'air ou de l'azote. L'humidité du gaz de séchage est régulée à une valeur exprimée, per exemple, en fonction du point de rosée, ce qui est connu pour donner des particules possédant une densité après tassement ou un diamètre aérodynamique spécifique. On préfère obtenir des particules possédant un diamètre géométrique moyen en volume supérieur à 5 microns et une densité après tassement inférieure à 0,4 g/cm?3¿ environ.

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