C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 15/869 (2006.01)
Patent
CA 2337963
A mutant herpesvirus has inactivating (preferably deletion) mutations at the locus of both native copies of the latency-active regulatory sequences. The resulting virus can be used as a latency-inactive virus as the basis of the vectors for gene delivery, as a helpervirus for production of amplicons, and as a base virus mutant for the construction of mutant virus vectors carrying synthetic latency-active regulatory sequences. Also described are synthetic/semisynthetic latency-active regulatory sequences and their use in CNS and other cells.
Selon cette invention, un herpèsvirus mutant présente des mutations d'inactivation (de préférence, de délétion) au locus des deux copies natives des séquences régulatrices actives pendant la latence. Le virus obtenu peut être utilisé comme virus inactif pendant la latence, en tant que base de vecteurs destinés à l'apport de gènes, comme virus assistant à la production d'amplicons et en tant que mutant de virus de base servant à construction de vecteurs de virus mutants transportant des séquences régulatrices synthétiques actives pendant la latence. L'invention concerne également des séquences régulatrices synthétiques / semi-synthétiques actives pendant la latence et leur utilisation dans des cellules du SNC ou autres. -
Efstathiou Stacey
Lachmann Robin Henry
Cambridge University Technical Services Limited
Sim & Mcburney
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