Latency associated peptides and uses therefor

Details Latency associated peptides and uses therefor Latency associated peptides and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) C07K 14/495 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2068204

An isolated nucleic acid sequence is provided that comprises a sequence that encodes a latency associated peptide having a molecular weight of about 75,000 when measured by non-reducing SDS-PAGE and capable of antagonizing a biological activity of mature TGF-.beta., provided that the sequence does not also encode a mature TGF-.beta.. The latency associated peptide so produced is useful therapeutically in blocking a deleterious activity of an endogenously released or exogenously administered TGF-.beta., alone or in combination with another exogenously administered or endogenously released immune regulator. It is also useful as a cotreatment therapy with mature TGF-.beta., which forms a latent associated complex therewith that is activatable at the desired site in vivo.

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