Latent procytotoxins and uses thereof

Details Latent procytotoxins and uses thereof Latent procytotoxins and uses thereof

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) A01N 37/18 (2006.01) A61K 36/14 (2006.01) A61K 38/00 (2006.01) A61K 51/00 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2624802

Disclosed are procytotoxins that comprise a latency associated peptide and a cytotoxic peptide, wherein a proteolytic cleavage site is provided between the latency associated peptide and the cytotoxic peptide. Also disclosed are compositions and methods for selectively destroying a target cell. Also disclosed are compositions and methods for treating cancer in a patient. Also disclosed are compositions and methods for providing latency to a cytotoxin.

L'invention concerne des procytotoxines comprenant un peptide associé à la latence et un peptide cytotoxique, un site de clivage protéolytique étant prévu entre le peptide associé à la latence et le peptide cytotoxique. L'invention concerne également des compositions et des procédés permettant de détruire de manière sélective une cellule cible et des compositions et des méthodes de traitement du cancer chez un patient. L'invention concerne enfin des compositions et des procédés permettant de conférer une latence à une cytotoxine.

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