Lawsonia derived gene and related hemolysin polypeptides,...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61P 1/00 (2006.01) C07H 21/04 (2006.01) C07K 14/195 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2372105

The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic hemolysin peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.

La présente invention concerne d'une manière générale des compositions thérapeutiques destinées au traitement et/ou à la prophylaxie de maladies intestinales chez des animaux et des oiseaux, provoquées ou exacerbées par Lawsonia intracellularis ou un autre micro-organisme similaire ou associé. L'invention concerne en particulier un nouveau gène dérivé de Lawsonia intracellularis codant pour un peptide, un polypeptide ou une protéine d'hémolysine immunogène, particulièrement utiles en tant qu'antigène dans des préparations vaccinales pour générer chez des animaux hôtes une immunité humorale contre Lawsonia intracellularis et les agents pathogènes associés. L'invention concerne également des méthodes de traitement et/ou de prophylaxie de telles maladies intestinales, ainsi que des agents de diagnostic et des procédés de détection de Lawsonia intracellularis ou de micro-organismes similaires ou associés.

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