C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/195 (2006.01) A61K 39/02 (2006.01) A61P 1/00 (2006.01) C07H 21/04 (2006.01) C07K 14/205 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2372102
The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic OmpH peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.
La présente invention concerne généralement des compositions thérapeutiques permettant de traiter et/ou de prévenir des infections intestinales chez des animaux et des oiseaux, ces infections étant provoquées ou aggravées par Lawsonia intracellularis ou tout autre micro-organisme identique ou apparenté. La présente invention concerne en particulier un nouveau gène dérivé de Lawsonia intracellularis, ce gène codant pour un peptide, un polypeptide, ou une protéine OmpH immunogène qui est particulièrement utile comme antigène dans des préparations vaccinales et qui confère une immunité humorale contre Lawsonia intracellularis, et ses agents pathogènes apparentés, à des hôtes animaux. Enfin, la présente invention concerne des méthodes permettant de traiter et/ou de prévenir les infections intestinales susmentionnées, ainsi que des agents diagnostiques et des procédures pour détecter Lawsonia intracellularis ou tout autre micro-organisme identique ou apparenté.
Hasse Detlef
Panaccio Michael
Sinistaj Meri
Agriculture Victoria Services Pty Ltd.
Australian Pork Limited
Smart & Biggar
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