C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/28 (2006.01) A61K 39/106 (2006.01) C12N 15/31 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2548750
The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularisinfections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection ofLawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.
La présente invention concerne notamment des acides nucléiques codant pour de nouvelles protéines de Lawsonia intracellularis. La présente invention concerne également des fragments d'ADN, des molécules d'ADN recombiné et des porteurs recombinés vivants. De plus, l'invention concerne des protéines codées par ces séquences nucléotidiques et leur utilisation dans la fabrication de vaccins. L'invention concerne également des vaccins permettant de combattre des infections par Lawsonia intracellularis et leurs méthodes de préparation. L'invention concerne finalement des tests de diagnostic destinés à la détection d'antigènes deLawsonia intracellularis et d'anticorps contre Lawsonia intracellularis.
Fetherstonhaugh & Co.
Intervet International B.v.
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