C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/195 (2006.01) A61K 39/02 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2554472
The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularisinfections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection ofLawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.
L'invention concerne entre autres des acides nucléiques codant de nouvelles protéines de Lawsonia intracellularis, ainsi que des fragments d'ADN, des molécules d'ADN recombinant et des supports recombinants vivants comprenant des séquences. L'invention concerne également des cellules hôtes comprenant de tels acides nucléiques, des fragments d'ADN, des molécules d'ADN recombinant et des supports recombinants vivants. En outre, l'invention concerne des protéines codées par ces séquences de nucléotides, ainsi que leur utilisation dans la production de vaccins. L'invention concerne par ailleurs des vaccins pour lutter contre des infections à Lawsonia intracellularis et des méthodes permettant de les préparer. L'invention concerne pour finir des essais diagnostiques pour détecter des antigènes de Lawsonia intracellularis et des anticorps agissant à l'encontre de Lawsonia intracellularis.
Fetherstonhaugh & Co.
Intervet International B.v.
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