Lawsonia protein useful as a component in subunit vaccine...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 47/48 (2006.01) A61P 31/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/195 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2605250

The present invention provides nucleic acid and amino acid sequences useful as the immunogenic portion of vaccines or immunogenic compositions effective for lessening the severity of the clinical symptoms associated with Lawsonia intracellularis infection or conferring protective immunity to an animal susceptible to such infection. Preferred amino acid sequences include at least 9 contiguous amino acids from SEQ ID NOS I (IDFKAKGVWDFNNFE), 3 (IDFKAKGVWDFNNFEWQQSSFMKG), or 7 (MICLG YKIS AGF AIGMIMVVLM). Thus, the nucleic acid sequences encoding such proteins, or the proteins themselves are included in vaccine compositions, together with veterinary-acceptable carrier and administered to an animal in need thereof.

L'invention concerne des séquences d'acides nucléiques et d'acides aminés que l'on utilise comme la partie immunogène de vaccins ou de compositions immunogènes efficaces pour atténuer la gravité des symptômes cliniques associés à l'infection de Lawsonia intracellularis ou conférer une immunité protectrice à un animal sensible à une telle infection. Les séquences d'acides aminés préférées comportent au moins 9 acides aminés contigus de SEQ ID NOS 1 (IDFKAKGVWDFNNFE), 3 (IDFKAKGVWDFNNFEWQQSSFMKG), OU 7 (MICLG YKIS AGF AIGMIMVVLM). Ainsi, les séquences d'acides nucléiques codant pour de telles protéines, ou les protéines elles-mêmes sont incluses dans des compositions de vaccins, avec un excipient acceptable à usage vétérinaire, et administrées à l'animal concerné.

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