Layered non-fouling, antimicrobial, antithrombogenic coatings

Details Layered non-fouling, antimicrobial, antithrombogenic coatings Layered non-fouling, antimicrobial, antithrombogenic coatings

C - Chemistry, Metallurgy

09

D

C09D 5/16 (2006.01) A61L 27/14 (2006.01)

Patent

CA 2745204

Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non- fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

Linvention concerne des substrats, facultativement revêtus dune sous-couche, sur lesquels sont greffés un ou plusieurs matériaux anti-encrassement. Le matériau polymère anti-encrassement peut être greffé sur divers matériaux de substrats fonctionnalisés, en particulier des substrats polymères et/ou des sous-couches polymères immobilisées sur un substrat. Les compositions décrites par les présentes sont très résistantes à labsorption de protéines, en particulier dans des milieux complexes, et conservent un haut degré dactivité anti-encrassement sur de longues périodes. Lesdites compositions peuvent également démontrer une activité antimicrobienne et/ou anti-thrombogène. Le matériau anti-encrassement peut être greffé sur un substrat fonctionnalisé ou facultativement à partir dune sous-couche sur le substrat, de préférence sans avoir dincidence significative sur les propriétés mécaniques et/ou physiques du matériau de substrat.

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