Ldl receptor-related proteins 1 and 2 and treatment of bone...

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) G01N 33/53 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2492044

LDL receptor-related proteins 1 and 2 (LRP-1 and LRP-2) and interaction between lactoferrin and LRP-1, LRP-2, or p42/44 MAP kinase in diagnosis and treatment of disorders such as bone or cartilage disorders. Also disclosed are methods of screening for related therapeutic compounds.

La présente invention concerne des protéines 1 et 2 associées aux récepteurs de LDL (LRP-1 et LRP-2) et une interaction entre la lactoferrine et les LRP-1, LRP-2, ou la MAP kinase p42/44, utiles dans le diagnostic et le traitement de lésions tels que des lésions osseuses ou cartilagineuses. L'invention concerne également des méthodes de criblage de composés thérapeutiques associés.

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