Leader sequences for directing secretion of polypeptides and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01)

Patent

CA 2589895

The present invention provides leader sequences that are useful for the production of heterologous secretable polypeptides; heterologous secreted polypeptides; nucleic acid constructs that encode such leader sequences and heterologous secreted polynucleotides; vectors that contain such nucleic acid constructs; recombinant host cells that contain such nucleic acid constructs; vectors, polypeptides, and methods of making and using such secreted polypeptides with such heterologous leader sequences.

La présente invention concerne des séquences de tête qui sont utilisées dans la production de polypeptides sécrétables hétérologues, de polypeptides sécrétés hétérologues, de constructions d'acides nucléiques qui codent ces séquences de tête et ces polypeptides sécrétés hétérologues, des vecteurs qui renferment ces constructions d'acides nucléiques, des cellules hôtes recombinantes qui contiennent de telles constructions d'acides nucléiques, des vecteurs, des polypeptides et des méthodes de conception et d'utilisation de tels polypeptides sécrétés avec ces séquences de tête hétérologues.

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