Lebetin peptides as platelet aggregation inhibitors

Details Lebetin peptides as platelet aggregation inhibitors Lebetin peptides as platelet aggregation inhibitors

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/04 (2006.01) C07K 7/08 (2006.01) C07K 14/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2275544

Lebetin peptides having the amino acid sequence: (X)mNKPPKKGPPNG(CFGHKIDRIGSHSGLGCNKVDDNKG)n(X)p where m=0 to 6, n=0 or 1, p=0 to 4 and each X is an amino acid residue are effective agents for the inhibition of platelet aggregation, and may be useful for the treatment of thrombosis or thromboembolism.

L'invention concerne des peptides de lebetine qui présentent la séquence d'acides aminés (X)¿m?NKPPKKGPPNG(CFGHKIDRIGSHSGLGCNKVDDNKG)¿n?(X)¿p? où m = 0 à 6, n = 0 ou 1, p = 0 à 4 et chaque X est un résidu d'acide aminé. Ces peptides sont des agents efficaces pour inhiber l'agrégation plaquettaire, et peuvent également être utiles pour traiter les thromboses ou les thrombo-embolies.

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