Lecithin-based microemulsions containing proteolytic enzymes...

A - Human Necessities – 61 – K

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A61K 8/66 (2006.01) A61Q 9/04 (2006.01)

Patent

CA 2255649

The invention refers to depilatory preparations containing: proteolytic enzymes solubilized in microemulsions, formed with lecithin, aliphatic hydrocarbon, alipathic alcohol and buffer solution pH 7 to 9, value corresponding to the pH range near the optimum pH value for the catalytic activity of the proteolytic enzymes, to be applied for permanent enzymic depilation. The application of these preparations will assure, as shown by our experimental studies, more permanent depilation than the one resulting from other depilatory methods. The application of these preparations is suitable for every type of skin (fatty-resistant or dry-sensitive). The present invention introduces the use of microemulsions as a medium for the facilitated penetration of the enzymic activity in the epithelial cells of the skin, as shown by our studies.

L'invention a trait à des préparations épilatoires contenant des enzymes protéolytiques solubilisées dans des micro-émulsions, constituées de lécithine, d'un hydrocarbure aliphatique, d'un alcool aliphatique et d'une solution tampon au pH compris entre 7 et 9, valeur correspondant à l'amplitude ionique proche de la valeur optimale de pH pour une activité catalytique des enzymes protéolytiques. On applique ces préparations aux fins d'une épilation permanente. Leur application assure, comme le prouvent nos études expérimentales, une épilation plus durable que celle que l'on obtient par d'autres techniques épilatoires. Ces préparations conviennent à tous les types de peau (grasses et résistantes ou sèches et sensibles). Cette invention introduit l'usage des micro-émulsions en tant que support facilitant la pénétration des enzymes dans les cellules épithéliales cutanées et partant, l'activité enzymatique, ainsi qu'en témoignent nos recherches.

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