C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) A61K 38/44 (2006.01) A61K 47/24 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2584406
A lecithinized superoxide dismutase (PC-SOD) composition useful as a base for medicines. The composition comprises PC-SOD's which are obtained by replacing one or more of the amino groups of a specific SOD with a lecithin residue represented by the following general formula (I) and which comprise, as main components, PC-SOD's(A) in which m amino groups [m is an integer of 1-4 and the average of m is 1.5-2.4] have been replaced with the lecithin residue, the PC-SOD's(A) comprising PC-SOD(a1) in which m=1, PC-SOD(a2) in which m=2, PC- SOD(a3) in which m=3, and PC-SOD(a4) in which m=4.
La présente invention a pour objet une préparation de superoxyde-dismutase lecthinisée (PC-SOD) pouvant être employée en tant que base de médicament. Ladite préparation comprend des PC-SOD obtenus en remplaçant un ou plusieurs groupements amine d'une SOD spécifique par un résidu lécithine de formule générale (I) ci-après, et incluant, au titre de composants principaux, des PC-SOD (A) dans lesquelles m groupements amine [m étant un entier compris entre 1 et 4, dont la valeur moyenne est comprise entre 1,5 et 2,4] ont été remplacés par le résidu lécithine, lesdits PC-SOD (A) comprenant les PC-SOD (a1) dans lesquels m = 1, les PC-SOD (a2) dans lesquels m = 2, les PC-SOD (a3) dans lesquels m = 3, et les PC-SOD (a4) dans lesquels m = 4.
Morizawa Yoshitomi
Murahashi Maki
Nakayama Toshiaki
Nomoto Hideo
Asahi Glass Company Limited
Ltt Bio-Pharma Co. Ltd.
Smart & Biggar
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