Lectin complex and method and probe for making same

Details Lectin complex and method and probe for making same Lectin complex and method and probe for making same

C - Chemistry, Metallurgy

07

K

167/129, 167/37,

C07K 16/00 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) G01N 33/577 (2006.01)

Patent

CA 1338619

A method of making a cytotoxic lectin complex having diminished non-specific toxicity by immobilizing on a solid support by a covalent linkage a ligand which has specific binding capacity for the oligosaccharide-binding sites of lectin to form a probe, binding the lectin to the ligand of the probe, and thereafter covalently bonding the lectin to the ligand to form a complex. The complex may then be severed from the solid support provided the first covalent linkage is cleavable, and may be covalently bonded to a monoclonal antibody.

532427

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