C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/145 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C07K 14/11 (2006.01) C07K 14/535 (2006.01) C12N 15/12 (2006.01) C12N 15/44 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2496384
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and server as a ligand for a cell surface polypeptide, as well as a vector comprising a nucleic acid encoding for such a fusion polypeptide, and a host cell comprising such nucleic acid. The present invention also provides a composition comprising an antigen bearing target and such a fusion polypeptide, as well as a composition comprising a virus or a cell and such a fusion polypeptide. The present invention further relates to a method of modulating an immune response in an animal using such compositions.
La présente invention concerne un polypeptide de fusion qui peut se fixer à une fraction de fixation à une surface cellulaire ( par exemple un glucide) et qui sert de ligand à un polypeptide de surface cellulaire, ainsi qu'un vecteur comprenant un acide nucléique codant pour ce polypeptide de fusion et qu'une cellule hôte comprenant cet acide nucléique. Cette invention concerne aussi une composition comprenant une cible portant un antigène et ce polypeptide de fusion ainsi qu'une composition comprenant un virus ou une cellule et ce polypeptide de fusion. Cette invention concerne enfin une technique de modulation d'une réponse immune d'un animal au moyen de ces compositions.
Segal Andrew H.
Young Elihu
Genitrix Llc
Opsanitx Llc
Torys Llp
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