C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C07K 14/42 (2006.01) C07K 16/16 (2006.01) C12M 1/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2599914
Disclosed is a polypeptide capable of binding to a sugar chain, particularly a high-mannose-type sugar chain bound to an antibody, more preferably a sugar chain bound to a chicken antibody. Also disclosed is a method for the purification of an antibody (specifically a chicken antibody) as a representative application of the polypeptide. Further disclosed in means for the purification. The polypeptide, BML-17, is a novel lectin made of 168 amino acid residues isolated from Bryopsis maxima. By using BML-17, it becomes possible to purify an antibody (e.g., a chicken antibody) readily and with high efficiency.
L~invention concerne un polypeptide capable de se lier à une chaîne de sucre, en particulier une chaîne de sucre à forte teneur en mannose liée à un anticorps, mieux encore une chaîne de sucre liée à un anticorps de poulet. Elle concerne également un procédé de purification d~un anticorps (spécifiquement un anticorps de poulet) comme application représentative du polypeptide. Elle concerne en outre un moyen de purification. Le polypeptide, BML-17, est une nouvelle lectine composée de 168 résidus d~acide aminé isolés de Bryopsis maxima. L~utilisation de BML-17 permet de purifier un anticorps (par exemple un anticorps de poulet) facilement et avec grande efficacité.
Hori Kanji
Matsuda Haruo
Blake Cassels & Graydon Llp
National University Of Corporation Hiroshima University
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