Lefty, lefty derivatives and uses thereof

Details Lefty, lefty derivatives and uses thereof Lefty, lefty derivatives and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2613320

The disclosure relates to Lefty derivatives and the uses of Lefty polypeptides as antagonists of the function of certain ligands such as Nodal, GDF-8 (Myostatin), and GDF-11. These derivatives may be fused to other functional heterologous proteins such as IgG, especially the Fc portion of IgG. Accrording to the disclosure, Lefty polypeptides are useful in the treatment of a variety of disorders, including, for example, neuronal diseases, muscle and bone conditions, and metabolic disorders.

L'invention concerne des dérivés du gène Lefty et les utilisations de polypeptides de Lefty comme antagonistes de la fonction de certains ligands tels que Nodal, GDF-8 (myostatine) et GDF-11. Ces dérivés peuvent être combinés avec d'autres protéines hétérologues fonctionnelles telles que IgH, en particulier la partie Fc de IgG. Selon l'invention, les polypeptides de Lefty s'utilisent dans le traitement d'une variété de troubles, intégrant par exemple des maladies neuronales, des pathologies musculaires et osseuses et des troubles du métabolisme.

Affiliated with

Also associated with

Rating

Lefty, lefty derivatives and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lefty, lefty derivatives and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lefty, lefty derivatives and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1838451