A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/008 (2006.01) A61K 39/39 (2006.01) C07K 14/025 (2006.01)
Patent
CA 2442298
The invention provides a DNA vaccine that elicits an immune response in the host in which it is administered, against Leishmania infection. The invention also relates to methods of administering the DNA vaccine. In one embodiment the DNA vaccine contains a vector encoding the A2 gene from Leishmania donovani in a physiologically acceptable medium. The invention further contains a biological adjuvant that includes a vector encoding a selected gene, the selected gene being capable of mediating the degradation of the cellular protein p53.
L'invention concerne un vaccin ADN qui élicite une réponse immunitaire dans l'hôte dans lequel il est administré contre l'infection à Leishmania. L'invention porte également sur des méthodes d'administration du vaccin ADN. Dans un mode de réalisation, le vaccin ADN contient un vecteur codant le gène A2 de leishmania donovani dans un milieu acceptable au plan physiologique. Le vaccin de l'invention contient un adjuvant biologique qui comporte un vecteur codant un gène sélectionné, capable de médier la dégradation de la protéine cellulaire p53.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Mcgill
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